CryoFAST™ – Fast Acquisition for Single Particle & Tomography
“ CryoFAST provides cutting edge AI-driven solutions for automating data collection. By lowering the requirement for human intervention, CryoFAST can help provide a more streamlined, higher throughput screening of Cryo-EM grids and increase the rate of data output….”
Vamseedhar Rayaprolu, PhD, Cryo-EM Microscopist 2, PNCC
Sample Screening requires manual selection of squares & holes on the grid using complex microscope control software
Screening can take up to 30 minutes per sample of detailed manual work
Data Collection can take up to 16 hours of overnight automated collection
Over 70% of data collected can be “junk” data and is wasted for processing
Today’s Cryo-EM image acquisition is Complex, Costly, and Failure-Prone
Deep learning models provide automated, unbiased 2D/3D data collection & data processing
Trained using proprietary and public datasets, Patent Pending1
Interfaces with Cryo-EM instrument control solutions
Enterprise workbench for lab operation (supports multiple users, samples/grids, & microscopes
1Patent Pending US No. 63/370,066
Uses AI/ML to automate Sample Screening & Data Collection
- Requires little to no user involvement with “push-button” automation
- Transfers screening insights to data collection
Includes an Easy-to-Use GUI and data management features
- Reduces complexity removing the need for advanced user training
- Enterprise workbench supporting multiple users, grids/samples, scopes
Improves Productivity and Accuracy
- Increases screening throughput by 2X
- Optimizes data collection reducing overnight scope time by 50%
- Improves data quality reducing wasted data to less than 30%
A portion of this research was supported by NIH grant U24GM129547 and performed at the PNCC at OHSU and accessed through EMSL (grid.436923.9), a DOE Office of Science User Facility sponsored by the Office of Biological and Environmental Research