Cryo-EM is a powerful technology for determining high-resolution 3D structures of biological macromolecules and bound compounds. It is complementary to X-ray crystallography, NMR, and other biophysical tools.
Benefits of cryo-EM in Drug Discovery
- Powerful tool to define binding modes of novel compounds in protein targets.
- Increased throughput for lead discovery or optimization.
- Acceleration, shortened time to trials/market.
Cryo-EM does require high-quality purified samples of interest. It also requires expertise in EM, sample prep, image processing techniques and can be expensive to build out cryo-EM facilities and experts.
HTI has years of expertise producing structures using cryo-EM. Our team has scientists and engineers on staff with deep expertise in structural biology, drug discovery, and data processing.
Our services enable high-resolution structure determination in a fast, affordable, and scalable manner. CryoDiscoveryTM is HTI’s proprietary machine learning based software that further automates the cryo-EM image processing workflow.